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- POFOL (Propofol) | Fast and Safe Anesthesia
Fast, safe, and effective anesthesia with Propofol | POFOL Injection I.V.
POFOL is an intravenous anesthetic based on Propofol, offering rapid onset, short recovery, high safety, and minimal drug interactions, making it the first choice for many physicians in outpatient surgeries, short-term anesthesia, and intensive care. *The gold standard in intravenous anesthesia (TIVA) with the highest global usage. POFOL induces effect in under 40 seconds with awakening in less than 10 minutes, providing precise control over anesthesia depth, without drug accumulation or toxic metabolites, and with protective effects for the brain and lungs.
- ✅ Rapid onset (within 40 seconds) and quick recovery (effective half-life 2–8 minutes)
- ✅ Does not require full liver or kidney function for metabolism
- ✅ No toxic metabolite production
- ✅ Anti-nausea and anti-vomiting effects
- ✅ Reduces intracranial pressure (ICP) and intraocular pressure
- ✅ Suitable for high-risk patients, children, and outpatient surgeries
- ✅ First Propofol drug with I.R.C code in Iran
⚙️ Applications
- Outpatient surgeries (Day Clinic)
- Anesthesia in children and adults
- Sedation in ICU, Dentistry (especially pediatric)
- Imaging (MRI, CT)
- Treatment of seizures, tetanus, ECT, resistant itching
- Application in spinal pain pumps.
🧪 Mechanism of Action
Activation of GABA-A receptors and inhibition of glutamate via NMDA receptors, resulting in central nervous system (CNS) depression.
⚠️ Possible Side Effects:
- Hypotension (especially with bolus injection)
- Respiratory depression
- Injection pain
- Propofol infusion syndrome with prolonged high-dose use
🧬 Drug Compatibility:
Minimal interaction with opioids, narcotics, and common pre-anesthetic drugs, making it a safe choice in complex treatment settings.
